What is 4-HO-MiPT?
4-Hydroxy-N-methyl-N-isopropyltryptamine (also known as 4-HO-MiPT, and Miprocin) is a novel psychedelic substance of the tryptamine class that produces psilocybin-like psychedelic effects when administered. It is part of a series of psychedelic substituted tryptamines such as 4-AcO-DMT, 4-HO-MET, 4-HO-DiPT that are considered to produce variations of the core psychedelic effects typified by psilocin.
This substance is relatively uncommon and has only a short history of human use. Alexander Shulgin evaluated its activity in humans in 1979, describing a trial of 12mg as a richly insightful and highly erotic experience. A description of 4-HO-MiPT is included in Shulgin’s 1997 book TiHKAL. Shulgin’s trials and other anecdotal reports suggest that 4-HO-MiPT is similar in activity to psilocin, the active component in psilocybin mushrooms.
Chemical Properties of 4-HO-MiPT
4-HO-MiPT is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-MiPT is substituted at R4 of its indole heterocycle with a hydroxyl (HO) functional group OH-. It also contains a methyl group and an isopropyl chain bound to the terminal amine RN of its tryptamine backbone (MiPT). 4-HO-MiPT is the N-substituted isopropyl homologue of 4-HO-DMT (Psilocin)
What are the Effects of 4-HO-MiPT?
4-HO-MiPT’s psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
4-HO-MiPT has many overlapping effects with substances like 1P-LSD and 4-HO-MET.
Some of the most commonly reported effects of 4-HO-MiPT are:
- Spontaneous bodily sensations
- Physical euphoria
- Visual hallucinations
- Increased music appreciation
- Colour enhancement
- Emotion enhancement
- Cognitive euphoria
Potential Side Effects of 4-HO-MiPT
- Muscle contractions
- Thought loops
- Feelings of impending doom
- Increased salivation
- Pupil dilation
4-HO-MiPT is classified as illegal in:
- United Kingdom
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