3-Methoxyphencyclidine (3-MeO-PCP) is an analog of the dissociative anesthetic phencyclidine (PCP). Although it first appeared in the scientific literature in the late 1970s and human use was discussed beginning in the late 1990s, it only became a widely used novel psychoactive substance (NPS) in the 2010s..
The drug produces dose-dependent disconnection from one’s body and surroundings, while also altering mood, anxiety, perception, and thinking. Often the effects are pleasurable, but its high potency can make it difficult to take the drug safely, as just a few milligrams can have a large impact on the experience.
Compared to a dissociative like ketamine or methoxetamine (MXE), it is typically more energizing. This can be positive at low to common doses because people find it easier to engage in daily activities and they may even be more motivated to be active, but it also makes high-dose experiences riskier because a user may not reliably lie down even when they are very impaired.
3-MeO-PCP also induces hypomanic- and manic-type effects that can be enjoyable at smaller doses—due to increased mood, confidence, energy, etc—yet can easily be dangerous at higher doses and in vulnerable people. As these effects increase, delusions can readily occur, potentially leading to injury, self-harm, risks to nearby people, and property damage.
The dose range encompassing the largest number of positive and relatively safe experiences is ~5 to 15 mg. Users should try light doses first and slowly increase the amount during subsequent experiences because relatively small doses can be intense for some users.
Compared with many drugs, the oral onset time is slower, and people may be minimally affected until ~90 min has passed, though some report effects a bit earlier. Because of the slow onset, it is very important to avoid redosing based on feeling the effects are inadequate during the first two hours.
- Light: 2 – 4 mg
- Common: 5 – 12 mg
- Strong: 13 – 17 mg
The core effects include a dose-dependent disconnection from your senses—e.g. choppy and distorted vision, numbness, and impaired taste and smell—and from your body. Because of these properties, users may feel as though they are no longer identical with their body and are instead riding around in a sort of vehicle or robot. Further, a user’s mind can seem as if it is physically positioned somewhere behind the body such that they are watching or controlling the body in a videogame-type manner.
- Mood enhancement
- Increased sociability (mostly at low to common doses)
- A hypomanic-like state that may include excessive confidence (e.g. in oneself and in unwise ideas and plans), high energy, the belief that one has special knowledge about things, and recklessness
- Analgesia (pain relief)
- Visual distortions, primarily of depth perception, acuity, and the shape/size of objects
- Heart rate (HR) and blood pressure (BP) increase
- Tinnitus (ringing in the ears)
- Anxiety and panic
- Cognitive impairment
- Distressing feelings of emotional detachment and anhedonia
Time distortion is frequently reported with common to strong doses. Distortion usually presents as time dilation, i.e. events seem to occur more slowly than they are. Users may feel like a simple activity, such as sending a message or walking to another room, took longer than it did. This can be coupled with a general sensation of everything in the world being slowed down.
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